Enabling allele-specific analysis of epigenome data

Project Description

Linking enhancers to genes is difficult. The state-of-the-art appraoch to link regulatory regions to genes is using the generalized Activity-by-Contact approach (gABC) see project site. The thesis is about enhancing the exisiting workflow to handle allele-specific epigenome data.

Research Goals

• Adjust the STARE pipeline to accommodate allele-specific epigenome signals
• Test the new pipeline on novel heart related epigenome data

Prerequisites

• Python programming
• ideally some knowledge about epigenomics

How to Apply

Send a short Email with a short motivation to the corresponding supervisor d.hecker|em.uni-frankfurt.de.